THE POWER OF THE HOST RESPONSE IN LIQUID BIOPSY AND TUMOR ENVIRONMENT

HOW GENE EXPRESSION WORKS

The human immune system is a complex early warning communication system between cells, tissues and environmental exposure. The billions of unique cells that circulate in our blood (Sender R et al., The total mass, and distribution of immune cells in the human body. Proc Natl Acad Sci 120: e2308511120, Epub 2023) can provide data points that reflect ongoing morbidities with high sensitivity. When the immune cells start to sense abnormalities, they change their RNA pool (transcriptome) upon activation of complex gene expression programs that drive functional responses. Analyzing gene expression profiles of large numbers of healthy individuals and of well-defined patient populations provides previously unknown insights and precision tools for monitoring integrated immune responses, development of more effective therapeutics, and precision clinical decision making.

GAIN EARLY INSIGHTS

Billions of unique immune cells that circulate in the human body hold genomic and transcriptomic information that reflect both early, prior, and ongoing abnormalities. Traditional methods to diagnose cancer, or measure therapy response, including liquid biopsy, mainly rely on tumor-derived signals such as circulating tumor proteins, circulating cell-free DNA or circulating tumor cells. These cancer signals are quite often associated with late stages of the disease limiting their utility and fail to reflect the host immune response to the disease and its treatment.

Novigenix is pioneering the field of Immuno-Transcriptomics with a robust platform that analyzes gene expression levels in whole blood from healthy individuals and well-defined patient populations, providing insights into early evidence of abnormalities, and response to therapeutic modalities. Combining AI-driven unbiased gene expression analysis with patient’s clinical manifestation provides intelligent insights in the development of effective therapies, monitoring systemic responses and in guiding treatment decisions.